Alzheimer’s disease is the most common form of dementia in older people. agree with Medline Plus, the US National Library of Medicine.
“Alzheimer’s disease begins slowly. It first affects the parts of the brain that control thought, memory and language. Besides, People with dementia may have difficulty remembering things that have happened recently or the names of people they know.explains the library.
However, recently, research by Harvard experts has given new hope to people who have a family history of this condition. The study noted that Alzheimer’s disease could be detected several years before the onset of cognitive damage.
Researchers from Massachusetts General Hospital, associated with Harvard Medical School, have shown that the early accumulation of tau and amyloid-β proteins can disrupt brain connectivity for years before signs of impairment are observed, like memory loss.
“However, we didn’t know how the wiring in the brain reacts to the accumulation of these proteins very early in the disease process, even before the symptoms,” explained Yakeel Quiroz, lead author of the article published in Proceedings of the National Academy of Sciences.
Particularly researchers conducted a study with members of a Colombian family, which showed that 1,500 members carry an autosomal dominant mutation (known as Presenilin-1 E280A), Thus, they believe that these carriers develop early Alzheimer’s disease, with almost 100% certainty, with mild cognitive impairment (MCI) at an average age of 45 and dementia at 51.
“We now know that there is a lot going on in the brains of people at risk of developing Alzheimer’s disease, even before signs of memory decline appear. we therefore hope that findings like these can improve our understanding of preclinical AD and help improve the selection of those who would benefit most from participation in clinical trials,” said Quiroz, director of Massachusetts General Hospital’s Familial Dementia Neuroimaging Laboratory and Multicultural Alzheimer’s Disease Prevention Program.
The stages of Alzheimer’s disease and how to fight it
According to the Mayo Clinic, a nonprofit organization dedicated to clinical practice, education, and research, there are five stages associated with Alzheimer’s disease:
1. Preclinical Alzheimer’s disease: this stage of the disease can last for years or even decades.
2. Mild cognitive impairment due to Alzheimer’s disease: In this phase, people have slight changes in their memory and thinking ability. People with mild cognitive impairment may have memory lapses when it comes to information that is usually easy to remember, such as conversations, recent events, or appointments.
3. Mild dementia due to Alzheimer’s disease: people may experience the following: loss of memory of recent events; difficulty solving problems, complex tasks and good judgment; personality changes; difficulty organizing and expressing thoughts or getting lost or misplacing personal belongings.
4. Moderate dementia due to Alzheimer’s disease: people may exhibit increasingly poor judgment and increasing confusion; experience even greater memory loss; need help with some daily activities; show significant changes in their personality and behavior.
5. Severe dementia due to Alzheimer’s disease: in the advanced stage of severe dementia due to Alzheimer’s disease, people usually lose the ability to communicate coherently; need for daily assistance with personal care; experience a decline in physical abilities.
However, it should be noted that no treatment can stop the disease, but some medications can help prevent symptoms from worsening for a limited time.
Additionally, the non-profit entity explained that Alzheimer’s disease cannot be prevented, but a number of lifestyle risk factors can be modified for those with this condition, such as: exercising, eating fresh produce, healthy oils and foods low in saturated fat, and quitting To smoke.